ea0047oc6 | Spotlight on Neuroendocrine tumours | Theranostics2016
Eberlein Uta
, Scherthan Harry
, Werner Rudolph A
, Lapa Constantin
, Bluemel Christina
, Peper Michel
, Buck Andreas K
, Port Matthias
, Lassmann Michael
Objectives: Radiation induces DNA double strand breaks (DSBs) that can be visualized and enumerated as microscopic γ-H2AX and 53BP1 foci. This study analysed the dose- and time-dependency of the DNA damage in blood lymphocytes in patients after a personalised high-activity 177Lu-DOTATATE treatment.Methods: We investigated multiple blood samples of three patients up to 96 h after personalised high-activity peptide receptor radionuclid...